Dynamic dual-isotope molecular imaging elucidates principles for optimizing intrathecal drug delivery
نویسندگان
چکیده
منابع مشابه
Optimizing SENSE for Dynamic Imaging
INTRODUCTION Although parallel imaging, such as SMASH [1] and SENSE [2], has been widely used in various MRI applications, these techniques have not yet been fully optimized to achieve the maximum speed enhancement for dynamic imaging applications. For a receiver system with L channels, the maximum acceleration factor R is L. However, when R approaches L, the SENSE model matrix can become very ...
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Advances in intrathecal analgesia and intrathecal drug delivery systems have allowed for a range of medications to be used in the control of pain and spasticity. This technique allows for reduced medication doses that can decrease the side effects typically associated with oral or parenteral drug delivery. Recent expert panel consensus guidelines have provided care paths in the treatment of noc...
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The aim of this principally experimental study is to understand from fluid mechanic principles why an insignificant anesthetic dose administered as a short bolus into the cerebrospinal fluid inside the subarachnoid space provides greater pain relief than a larger dose continuously injected over a longer period. The subarachnoid space is modeled as an annular gap of constant or slowly varying cr...
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OBJECTIVE The objective of this study was to identify best practices and provide guidance to clinicians to ensure safety and optimize intrathecal drug delivery for chronic intractable pain. METHODS Twelve experienced pain medicine practitioners-eight anesthesiologists, one neurosurgeon, one physiatrist, one clinical psychologist, and one advanced practice registered nurse-from the United Stat...
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Intrathecal drug delivery is an effective pain management option for patients with chronic and cancer pain. The delivery of drugs into the intrathecal space provides superior analgesia with smaller doses of analgesics to minimize side effects while significantly improving quality of life. This article aims to provide a general overview of the use of intrathecal drug delivery to manage pain, dos...
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ژورنال
عنوان ژورنال: JCI Insight
سال: 2016
ISSN: 2379-3708
DOI: 10.1172/jci.insight.85311